Search results for "Electrospun scaffold"

showing 5 items of 5 documents

Bi-layered polyurethane – Extracellular matrix cardiac patch improves ischemic ventricular wall remodeling in a rat model

2016

As an intervention to abrogate ischemic cardiomyopathy, the concept of applying a temporary, local patch to the surface of the recently infarcted ventricle has been explored from a number of design perspectives. Two important features considered for such a cardiac patch include the provision of appropriate mechanical support and the capacity to influence the remodeling pathway by providing cellular or biomolecule delivery. The objective of this report was to focus on these two features by first evaluating the incorporation of a cardiac extracellular matrix (ECM) component, and second by evaluating the impact of patch anisotropy on the pathological remodeling process initiated by myocardial …

0301 basic medicineMaterials scienceAngiogenesisPolyurethanesBiophysicsMyocardial IschemiaInfarctionBiocompatible MaterialsBioengineeringCeramics and Composite02 engineering and technologyCardiac ECMBiomaterialsExtracellular matrixRats Sprague-Dawley03 medical and health sciencesVentricular Dysfunction LeftAbsorbable ImplantsMaterials TestingmedicineAnimalsMyocardial infarctionCardiac patchIschemic cardiomyopathyTissue ScaffoldsVentricular RemodelingVentricular wallHydrogelsRecovery of Function021001 nanoscience & nanotechnologymedicine.diseaseBiomaterialExtracellular MatrixRatsCompliance (physiology)Electrospun scaffold030104 developmental biologymedicine.anatomical_structureTreatment OutcomeBiophysicVentricleRats Inbred LewMechanics of MaterialsCeramics and CompositesFemale0210 nano-technologyStructure - functionBiomedical engineering
researchProduct

Micro-Architecture Based Structural Model for Elastomeric Electrospun Scaffolds.

2010

Elastomeric Electrospun Scaffolds Micro-Architecture Soft Tissue Engineering FEM analysi
researchProduct

Production of a Double-Layer Scaffold for the “On-Demand” Release of Fibroblast-like Limbal Stem Cells

2019

The production and characterization of a double layer scaffold, to be used as a system for the “on demand” release of corneal limbal stem cells are here reported. The devices used in the clinics and proposed so far in the scientific literature, for the release of corneal stem cells in the treatment of limbal stem cell deficiency, cannot control the in vivo space-time release of cells since the biomaterial of which they are composed is devoid of stimuli responsiveness features. Our approach was to produce a scaffold composed of two different polymeric layers that give the device the appropriate mechanical properties to be placed on the ocular surface and the possibility of releasing the stem…

ScaffoldMaterials sciencePolyestersFibroblast-like limbal stem cells Limbal stem cells deficiency On demand cell releasing systems Electrospun scaffold Hyaluronic acid based film coatingBiocompatible Materials02 engineering and technologyLimbus CorneaeLimbal stem cell deficiencyCornea03 medical and health sciences0302 clinical medicineCell Line TumorOn demandmedicineHumansGeneral Materials ScienceFibroblastCells CulturedDouble layer (biology)Stem CellsEpithelium CornealEpithelial CellsFibroblasts021001 nanoscience & nanotechnologyeye diseasesCell biologymedicine.anatomical_structureSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoMicroscopy Electron Scanning030221 ophthalmology & optometrysense organsStem cell0210 nano-technologyStem Cell TransplantationACS Applied Materials & Interfaces
researchProduct

Analysis of Electrospun Scaffolds Micro - Architectural Data.

2009

Settore ING-IND/14 - Progettazione Meccanica E Costruzione Di MacchineElectrospun scaffolds image analysis micro-architecture soft tissue engineering.
researchProduct

STRUCTURAL DETERMINISTIC MODELING DESIGN AND FABRICATION OF ELECTROSPUN SCAFFOLDS FOR SOFT TISSUE ENGINEERING

2011

The research fields of tissue engineering, biomechanics and regenerative medicine continue to evolve in response to the ever growing need for tissue replacement options. These fields aim to restore, maintain, or improve tissue or whole organ function. This doctoral studies focus on the development and experimental validation of a structural deterministic modeling strategy to: A) guide tissue engineering scaffold design, B) provide a better understanding of cellular mechanical and metabolic response to local micro-structural deformations. Targeted clinical application was the pulmonary heart valve. Electrospinning was selected as the optimal platform technology to implement, validate and tes…

Settore ING-IND/14 - Progettazione Meccanica E Costruzione Di MacchineMODELING DESIGNELECTROSPUN SCAFFOLDS
researchProduct